Low-Birth Weight Babies Linked to Early Mortality in Parents
Review
STOCKHOLM, June 29-Babies born too soon and too small may be grim harbingers of early mortality in mothers and, to a lesser degree, in fathers."
This blog is destined to keep general references sellected in the WEB. The address of the main blog is http://amicor.blogspot.com.
É uma das fraquezas do ser humano: pelo poder (e pelo dinheiro que compra o poder) se faz qualquer coisa. A própria Bíblia começa por aí, e está cheia de histórias de comportamento duvidoso na busca de privilégios. Existem até explicações biológicas para a voracidade no controle do terreno, e na busca de domínio sobre potenciais competidores.
Alimentamos a fantasia de que somos seres por natureza virtuosos, capazes de respeitar valores e direitos dos outros, e costumamos colocar a responsabilidade do deslize fora de nós, buscando uma serpente perversa, para explicar a virtude corrompida. Mas até o adágio diz que “todo o mundo um tem seu preço”...
Quando escândalos alcançam as manchetes nos damos conta de fenômenos que necessitam da surdina para se desenvolver, ou que de tão freqüentes deixamos de estranhar. Entretanto, somente através da transparência, permitindo o controle social, se consegue frear o impulso da corrupção.
Uma das agências que se ocupa do assunto, no relatório deste ano, cujo mote é “um mundo construído em cima de propinas” estima em torno de um trilhão de dólares o volume da sangria anual que se desvia de suas legítimas finalidades e que termina movendo o mundo através de interesses secundários.
Resultados de pesquisa realizada no ano passado, tentando estimar o grau de corrupção das instituições pelo mundo afora, colocaram em primeiro e segundo lugar partidos políticos e poder legislativo, o que não nos causa surpresa. Em seguida vem a polícia e todo o sistema judiciário, recursos nos quais deveríamos confiar no controle da ordem social. O setor privado e de negócios se situa em 6º lugar, provavelmente pelo equilíbrio já estruturado pela concorrência de mercado.
Em posição intermediária situam-se a mídia, os serviços médicos e a educação.
Por falar na minha profissão, é de se admirar o grau de preservação ainda existente, apesar de todos os desafios e interesses secundários de dentro e de fora da profissão (num dos setores que mais se expande no mundo atual, e no qual vem se perdendo a força da relação simples e do contrato claro entre o médico e o paciente): intermediações de todo tipo, indústria hospitalar, farmacêutica e de equipamentos. De muitas formas se manifesta o abuso nas relações sociais e a corrupção. Não é somente com dinheiro, mas também com favores, presentes, tráfego de influência e de ilusões, nepotismo, corrupção passiva e outras.
As tensões sociais, aliadas às fragilidades e desvios da personalidade rompem o tecido social, as relações de confiança, o contrato de tolerância, a ordem das prioridades e terminam com a solidariedade. Fica-se exposto a toda sorte de abusos e de exploração, cada um encontrando justificativa no clima de luta pela sobrevivência, na imitação do comportamento grupal, na bruma da perda da identidade, na impunidade, nos impulsos selvagens da discriminação, e no desespero ou disputa por espaço e expressão narcisista.
A discussão deste tema não pode servir como desculpa para também entrar numa competição que só pode levar ao desastre global, mas para alertar para uma permanente vigilância e reconstrução de uma sociedade com mais transparência.
Medscape Medical News 2005. © 2005 Medscape
David C. Holzman
May 27, 2005 (Boston) — The recent federal study by the Centers for Disease Control and Prevention (CDC) suggesting that extra pounds could be risk free raised concerns by panelists at a meeting yesterday at the Harvard School of Public Health (HSPH) in Boston, Massachusetts. The study published in the April 20 issue of JAMA had inspired the popular press to celebrate the prospect of gastronomy without guilt.
The meeting panelists criticized the study's methodology and suggested that the conclusions were biologically implausible and contrary to numerous other analyses.
The study, which was led by Katherine M. Flegal, PhD, of the National Center for Health Statistics, CDC, had found an excess of nearly 112,000 deaths annually among the obese (body mass index [BMI], 30 kg/m2). While significant, that was a huge decrease from a CDC study last year, which found an excess of 365,000 deaths in this group, suggesting that obesity was second only to smoking on the list of the top
JoAnn Manson, MD, MPH, DrPH, a panelist who is professor of medicine, Harvard Medical School Chief, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital told attendees at the meeting that the study's conclusions lacked plausibility given that obesity causes all the elements of metabolic syndrome. Further, she noted that losing weight intentionally mitigated these elements.
Dr. Manson charged that inasmuch as obesity leads to hypertension, insulin resistance, hyperglycemia, and diabetes, abnormal lipids, and inflammation and that modest weight loss was shown to reduce blood pressure, blood glucose and insulin levels, and diabetes and to increase high-density lipoprotein cholesterol levels, the results of the Flegal study appeared to be biologically implausible. Moreover, she cited a 2004 JAMA analysis encompassing 136 studies and 22,000 patients that showed that bariatric surgery mitigated or eliminated hypertension, diabetes, hyperlipidemia, and obstructive sleep apnea in a majority of patients.
Michael Thun, MD, MS, vice president of epidemiology and surveillance research at the American Cancer Society told attendees that the Cancer Prevention Study II had shown that both breast cancer mortality in women and colon cancer mortality in men climbed steadily with BMI, the latter rising from a relative risk of less than 1 at BMIs of less than 22 kg/m2 to nearly 2 at BMIs of more than 32.5 kg/m2. That study included 1.2 million people in 50 states.
But, the crux of the problem with the CDC study, according to several panelists, was failure to control for "reverse causality," a theme that was echoed by several panelists. Implicit in the study's methodology was the notion that leanness can lead to death, when in fact, leanness may merely be an adverse effect of the sickness that leads to death.
For example, chronic diseases such as cancer, cirrhosis, and chronic obstructive pulmonary disease can lead to wasting. Even conditions that may result from overweight, such as heart disease, can ultimately lead to weight loss. The overweight may precede the disease-induced weight loss by years or even decades, Meir Stampfer, MD, DrPH, comoderator of the meeting, and chair, the department of epidemiology, HSPH, told Medscape. And it is possible for the elderly — people in their 70s and 80s — to lose weight, often due to chronic conditions.
Despite the uncertainties about using BMI in the elderly, the CDC study erred in using it as a predictor of death, Dr. Manson told Medscape. That, Dr. Manson said, was one of the two biggest difficulties with the study.
The other was the short follow-up. NHANES I had a 19-year follow-up, but NHANES II and III had only 14 and 9 years, respectively. Extrapolating the death rate in NHANES I, the cohort with the longest (19 years) mean follow-up, to the entire U.S. population resulted in nearly 300,000 deaths annually attributable to obesity, Dr. Manson told attendees at the meeting, while extrapolating cohorts II and III, with follow-ups of 14 and 9 years, respectively, resulted in 29,917 and 43,650 deaths from obesity, respectively. The Flegal study was based on data from all three NHANES cohorts.
Panelist Graham Colditz, MD, DrPH, of HSPH told attendees that "The public health response has ignored the morbidity burden that is real. Dr. Colditz cited data showing that type 2 diabetes, cholelithiasis, hypertension, and coronary heart disease all rise steadily with BMI, and said that direct costs totaled $70 billion annually, 7% of the U.S. healthcare budget.
Donna Stroup, PhD, director of the coordinating center for health promotion at CDC, represented her agency on the panel. The authors of the Flegal study all declined invitations. Dr. Stroup told attendees the CDC study reflected a "remarkable" decline in risk factors, such as high blood pressure among the obese, for the last four years. But asked by Medscape about the panelists' criticisms of the study, Dr. Stroup told attendees that "I would not disagree with my colleagues on the [HSPH] program." Dr. Stroup added that she did not disagree with their numbers.
The 300,000 deaths extrapolated from NHANES I corresponded with an analysis of mortality from obesity that Dr. Manson and others published in JAMA in 1999, based on data from six prospective cohort studies including Nurses' Health Study, NHANES I, and the Framingham Heart study, Dr. Manson told attendees at the meeting. When restricting the data to never/nonsmokers, that analysis attributed 325,000 deaths/year to obesity.
Harvard Forum: "Weighing the Evidence: A Forum to Examine the Latest News About Overweight, Obesity and Mortality in
Reviewed by Gary D. Vogin, MD
David C. Holzman is a freelance writer for Medscape.